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KMID : 0357920090430050448
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Korean Journal of Pathology
2009 Volume.43 No. 5 p.448 ~ p.452
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Comparison of Cytologic Evaluation between Conventional Method and CellprepPlus® Liquid-Based Cytology in Body Fluid
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Koo Ji-Hae
Lee Ho-Chang
Song Hyung-Geun
Han Hye-Sook
Lee Ki-Hyeong
Choe Kang-Hyeon
Lee Kee-Man
Lee Ok-Jun
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Abstract
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Background: Assessment of body fluid cytology is a useful means of evaluating a metastatic tumor. Liquid-based cytology (LBC) has been developed as a replacement for the conventional Papanicolaou (CP) test. This study was performed to compare CellprepPlus® LBC with CP in cytologic diagnosis.
Methods: Body fluid samples (n=188, including 72 peritoneal fluid and 116 pleural fluid samples) were divided equally and analyzed by both CellprepPlus® and CP.
Results: CellprepPlus® revealed distributed thin layers of non-overlapping cells. All CellprepPlus® preparations were adequate, while 18 (9.57%) CP preparations were inadequate. The respective diagnostic rates of CellprepPlus® and CP were 75.0% and 76.1% negative, 10.6% and 6.38% atypical, 5.85% and 2.66% suspicious, and 8.51% and 5.32% malignant. Of the 58 confirmed cases, the sensitivity of CellprepPlus® and CP was 94.4% and 73.3%, respectively, and the negative predictive value was 97.2% and 87.9%, respectively.
Conclusions: CellprepPlus® LBC has better sensitivity and negative predictive value, and produces higher quality slide preparations than than CP, making it suitable as in screening of body fluid as a cytologic diagnostic tool.
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KEYWORD
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Body fluids, Cytology, Neoplasm metastasis
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